Canine Purkinje Fibers
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چکیده
and glucocorticoid excretory responses to alpha 1-24 ACTH (Cortrosyn) in sodium-deplctcd normal man. J Clin Endocrinol Mctab 36: 30-35, 1973 14. Sncdccor GW. Cochran WG Statistical Methods, ed 6. Ames, Iowa State University Press, 1969, p 246 15. Dunnett CW: New tables for multiple comparisons with a control. Biometrics 20: 482-491, 1964 16 Laragh JH: Vasoconstnction-volume analysis for understanding and treating hypertension, the use of renin and aldostcrone profiles. Am J Med 55: 261-272, 1973 17. Kern DC, Weinberger MH, Mayes DM, Nugent CASaline suppression of plasma aldosterone in hypertension. Arch Intern Med 128: 380-386, 1971 18. Krakoff LR: Goodwin FJ, Baer L, Torres M, Laragh JH: The role of rcnin in the exaggerated natnuresis of hypertension. Circulation 42: 335-345, 1970
منابع مشابه
An Inotropic Action Caused by Muscarinic Receptor Subtype 3 in Canine Cardiac Purkinje Fibers
Objective. The objective of this study was to investigate the inotropic mechanisms and the related muscarinic receptor subtype of acetylcholine (ACh) in canine cardiac Purkinje fibers. Materials and Methods. Isolated Purkinje fiber bundles were used for the measurement of contraction. The receptor subtype was determined using PCR and real-time PCR methods. Results. ACh evoked a biphasic respons...
متن کاملDistinct patterns of connexin expression in canine Purkinje fibers and ventricular muscle.
Electrical conduction is more rapid in Purkinje fibers than in ventricular muscle, which are distinct cardiac tissues that have different active and passive electrophysiological properties. We have recently demonstrated that canine myocardium contains multiple gap junction proteins or connexins that form channels with unique electrophysiological properties. To determine whether differences in c...
متن کاملAn Analysis of Arrhythmias Induced by Ouabain in Intact Dogs.
• The mechanism of cardiac arrhythmias induced by digitalis compounds has been investigated recently by the microelectrode technique. Coraboeuf et al. found that the automaticity of the canine "tissu nodal" was enhanced by administration of digitalis. This finding was confirmed by Dudel and Trautwein for canine Purkinje fibers. Also, the action of glycosides on transmembrane potentials of ventr...
متن کاملInitiation of sustained rhythmic activity by single propagated action potentials in canine cardiac Purkinje fibers exposed to sodium-free solution or to ouabain.
Canine cardiac Purkinje fibers were exposed to sodium-free solutions containing 128 mM tetraethylammonium chloride and 16.2 mM calcium. Some fibers exposed to these solutions were spontaneously active. Other fibers were quiescent, but they could be thrown into sustained rhythmic activity by a single driven action potential; the sustained activity resulted from the depolarizing phase of an oscil...
متن کاملEffect of acetylcholine on automaticity of canine Purkinje fibers.
The effect of acetylcholine on automaticity of Purkinje fibers was studied in isolated canine false tendon preparations with conventional microelectrode techniques. Of 15 preparations with the control spontaneous rate of 12-60 beats/min, acetylcholine in a concentration of 0.5 mug/ml decreased the spontaneous rate by 20-87% in 13 preparations. This decrease in automaticity was due to a decrease...
متن کاملEffects of alpha-adrenergic stimulation on intracellular sodium activity and automaticity in canine Purkinje fibers.
Approximately 60% of adult canine Purkinje fibers respond to alpha 1-adrenergic stimulation with a decrease in automaticity. Recent studies of disaggregated Purkinje myocytes have suggested that this negative chronotropic effect results from alpha 1-adrenergic activation of the Na-K pump. In this study we evaluated 1) whether Na-K pump activation is associated with the negative chronotropic eff...
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